Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Synucleinopathies are a group of neurodegenerative diseases characterized by the
accumulation of α-synuclein aggregates in neurons, nerve fibers or glial cells. Three main …

As one of the most prevalent post-transcriptional epigenetic modifications, N5-
methylcytosine (m5C) plays an essential role in various cellular processes and disease …

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian
neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active …

Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …

Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are
increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a …

DNA breaks at protein-coding sequences are well-established threats to tissue homeostasis
and maintenance. They arise from the exposure to intracellular and environmental …

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …

Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be
a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring …