Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …

Immunometabolism is an emerging field at the intersection of immunology and metabolism.
Immune cell activation plays a critical role in the pathogenesis of cardiovascular diseases …

The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during
postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the …

Affecting approximately 25% of the global population, steatotic liver disease (SLD) poses a
significant health concern. SLD ranges from simple steatosis to metabolic dysfunction …

Bile acids (BAs) and bilirubin, primarily known for their role in lipid metabolism and as heme
catabolite, respectively, have been found to have diverse effects on various physiological …

Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial
infection. However, these processes may also be activated during the pathogenesis of non …

In failing cardiomyocytes, depletion of carnitine acetyltransferase promotes cholesterol
catabolism via the bile acid synthesis pathway. The intracellular accumulation of bile acid …