Alzheimer's disease (AD) is the most common type of dementia characterized by the
deposition of amyloid beta (Aβ) plaques and tau-neurofibrillary tangles in the brain. Visceral …

Alzheimer's disease (AD) is a prevalent neurodegenerative disease predominantly affecting
millions of elderly people. To date, no effective therapy has been identified to reverse the …

Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

Dementias, including the type associated with Alzheimer's disease (AD), are on the rise
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging
and AD are associated with apparent metabolic alterations. As developing effective …

Neurons critically depend on mitochondria for ATP production and Ca2+ buffering. They are
highly compartmentalized cells and therefore a finely tuned mitochondrial network …

Aims Insulin action in the brain influences cognitive processes, peripheral metabolism and
eating behaviour. However, the influence of age and peripheral insulin sensitivity on brain …

Alzheimer's disease (AD; progressive neurodegenerative disorder) is associated with
cognitive and functional impairment with accompanying neuropsychiatric symptoms. The …

Psychiatric and neurodegenerative disorders are amongst the most prevalent and
debilitating diseases, but current treatments either have low success rates, greatly due to the …