[HTML][HTML] Molecular mechanisms of tumor resistance to radiotherapy

Y Wu, Y Song, R Wang, T Wang - Molecular Cancer, 2023 - Springer
Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

G-quadruplex DNA: a novel target for drug design

FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Nanomedicine combats drug resistance in lung cancer

X Zheng, X Song, G Zhu, D Pan, H Li, J Hu… - Advanced …, 2024 - Wiley Online Library
Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …

[HTML][HTML] Potential effects of geraniol on cancer and inflammation-related diseases: A review of the recent research findings

R Ben Ammar - Molecules, 2023 - mdpi.com
Geraniol (GNL), a natural monoterpene, is found in many essential oils of fruits, vegetables,
and herbs, including lavender, citronella, lemongrass, and other medicinal and aromatic …

Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer

A Sarkar, A Paul, T Banerjee, A Maji, S Saha… - European Journal of …, 2023 - Elsevier
Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …

[HTML][HTML] Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery

Y Zhang, X Tian, Z Wang, H Wang, F Liu… - Frontiers in Molecular …, 2023 - frontiersin.org
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands
and creates specific structures based on the complementary base pairing principle. These …

Applications of oxetanes in drug discovery and medicinal chemistry

G Huang, D Hucek, T Cierpicki, J Grembecka - European Journal of …, 2023 - Elsevier
The compact and versatile oxetane motifs have gained significant attention in drug discovery
and medicinal chemistry programs. This review presents an overview of the diverse …

[HTML][HTML] Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review

Q Cao, X Wu, Q Zhang, J Gong, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma
(MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant …

[HTML][HTML] Molecular mechanism of palmitic acid and its derivatives in tumor progression

X Wang, C Zhang, N Bao - Frontiers in oncology, 2023 - frontiersin.org
Palmitic acid (PA) is a saturated fatty acid commonly found in coconut oil and palm oil. It
serves as an energy source for the body and plays a role in the structure and function of cell …

Prostate cancer and microRNAs: New insights into apoptosis

J Gupta, WK Abdulsahib, AT Jalil, DS Kareem… - … -Research and Practice, 2023 - Elsevier
Prostate cancer (PCa) is known as one of the most prevalent malignancies globally and is
not yet curable owing to its progressive nature. It has been well documented that Genetic …