Currently, chemoresistance is a major challenge that directly affects the prognosis of
patients with colorectal cancer (CRC). In addition, hypoxia is associated with poor prognosis …

Background The endoplasmic reticulum stress (ERS) pathway, inositol-requiring enzyme-1
alpha-X-box binding protein-1 (IRE1α-XBP1), has been considered as a critical factor of …

Significance: Several therapeutic strategies for cancer treatments have been developed with
time, and significant milestones have been achieved recently. However, with these novel …

Abstract The protein Bcl-2, well-known for its anti-apoptotic properties, has been implicated
in cancer pathogenesis. Identifying the primary gene responsible for promoting improved …

In situ monitoring multidrug release in complex cellular microenvironments is significant, and
currently, it is still a great challenge. In this work, a smart nanocarrier with the capability of …

Small-molecule prodrug nanoassembly technology with a unique advantage in off-target
toxicity reduction has been widely used for antitumor drug delivery. However, prodrug …

Background β-Elemene (IUPAC name:(1 S, 2 S, 4 R)− 1-ethenyl-1-methyl-2, 4-bis (prop-1-
en-2-yl) cyclohexane), is a natural compound found in turmeric root. Studies have …

摘要目的: 探讨靶向抗凋亡蛋白Bcl-2 克服非小细胞肺癌EGFR-TKIs 耐药的作用及重定位Bcl-2
靶向抑制剂用于克服耐药的可行性. 方法: 通过药物浓度梯度递增法构建非小细胞肺癌多代 …

Osteosarcoma is a prevalent malignant bone tumor and incomplete surgical resection of the
tumor often results in higher rates of local recurrence. To tackle this issue, there is an urgent …

Apoptosis signaling controls the cell cycle through the protein–protein interactions (PPIs) of
its major B-cell lymphoma 2-associated x protein (BAX) and B-cell lymphoma 2 protein (Bcl …