γδ T cells for cancer immunotherapy: a systematic review of clinical trials

JPH Fisher, J Heuijerjans, M Yan, K Gustafsson… - …, 2014 - Taylor & Francis
γδ T cells contribute to the front line of lymphoid antitumor surveillance and bridge the gap
between innate and adaptive immunity. They can be readily expanded to high numbers in …

A third shot at EGFR: new opportunities in cancer therapy

S Guardiola, M Varese, M Sanchez-Navarro… - Trends in …, 2019 - cell.com
Epidermal growth factor receptor (EGFR) inhibitors were among the first type of targeted
agents discovered in cancer and currently constitute the standard of care for a wide range of …

Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer

JJ Yang, HJ Chen, HH Yan, XC Zhang, Q Zhou, J Su… - Lung cancer, 2013 - Elsevier
BACKGROUND: There is no published overview of epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor (TKI) failure modes in advanced non-small-cell lung cancer …

Development of dual inhibitors targeting epidermal growth factor receptor in cancer therapy

L Tan, J Zhang, Y Wang, X Wang, Y Wang… - Journal of Medicinal …, 2022 - ACS Publications
Epidermal growth factor receptor (EGFR) is of great significance in mediating cell signaling
transduction and tumor behaviors. Currently, third-generation inhibitors of EGFR, especially …

The frequency of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC): routine screening data for central Europe from a cohort study

C Boch, J Kollmeier, A Roth, S Stephan-Falkenau… - BMJ open, 2013 - bmjopen.bmj.com
Objectives Owing to novel therapy strategies in epidermal growth factor receptor (EGFR)-
mutated patients, molecular analysis of the EGFR and KRAS genome has become crucial …

[HTML][HTML] Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and …

H Liu, Y Wu, T Lv, Y Yao, Y Xiao, D Yuan, Y Song - PLoS one, 2013 - journals.plos.org
Background The aim of this study was to assess the role of skin rash in predicting the
efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and the …

Challenges in assessing solid tumor responses to immunotherapy

LF Chai, E Prince, VG Pillarisetty, SC Katz - Cancer gene therapy, 2020 - nature.com
With the advent of immunotherapy as an integral component of multidisciplinary solid tumor
treatment, we are confronted by an unfamiliar and novel pattern of radiographic responses …

Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review

C Wang, Y Zhang, T Zhang, J Xu, S Yan, B Liang… - International Journal of …, 2023 - Elsevier
Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

[HTML][HTML] γδ T lymphocytes as a first line of immune defense: old and new ways of antigen recognition and implications for cancer immunotherapy

A Poggi, MR Zocchi - Frontiers in immunology, 2014 - frontiersin.org
Among γδT cells, the Vδ1 subset, resident in epithelial tissues, is implied in the defense
against viruses, fungi, and certain hematological malignancies, while the circulating Vδ2 …

Serum concentration of erlotinib and its correlation with outcome and toxicity in patients with advanced-stage NSCLC

O Fiala, P Hosek, M Pesek, J Finek, J Racek… - Anticancer …, 2017 - ar.iiarjournals.org
Background: Erlotinib is a tyrosine kinase inhibitor targeting epidermal growth factor
receptor (EGFR); it is used in the treatment of advanced non-small cell lung cancer …