In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded
that an abdominal distribution of fat for a given BMI is associated with increased insulin …

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by a
constellation of adult onset phenotypes consistent with an acceleration of intrinsic biological …

Age-related degenerative and malignant diseases represent major challenges for health
care systems. Elucidation of the molecular mechanisms underlying carcinogenesis and age …

Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated
aging. While the underlying constitutional mutation leads to accelerated rates of DNA …

LMNA encodes the A-type lamins that are part of the nuclear scaffold. Mutations in LMNA
can cause a variety of disorders called laminopathies, including Hutchinson-Gilford progeria …

Segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs
of premature aging affecting more than one tissue or organ. A prototypic example is the …

Until recently, Werner syndrome (WS) had been considered to be a model of accelerated
aging. The Werner gene (WRN) was identified in 1996 (1) and was subsequently shown to …

Transient ischemic attack (TIA) is a predictor for cerebral infarction (CI), and early diagnosis
of TIA is extremely important for the prevention of CI. We set out to identify novel antibody …

Segmental progeroid syndromes with lipodystrophy are extremely rare, heterogeneous, and
complex multi-system disorders that are characterized by phenotypic features of premature …

Werner syndrome is a premature ageing disorder caused by biallelic variants in the WRN
gene. WRN encodes a dual DNA helicase/exonuclease enzyme. Molecular diagnosis is …