Methylenetetrahydrofolate reductase (MTHFR) links the folate cycle to the methionine cycle
in one-carbon metabolism. The enzyme is known to be allosterically inhibited by SAM for …

Background: A polymorphism is a variant within a gene that does not necessarily affect its
function, unlike a pathogenic mutation. Genetic testing for two common polymorphisms in …

Research evaluating the role of the 5, 10-methylenetetrahydrofolate reductase (MTHFR
C677T) gene in schizophrenia has not yet provided an extended understanding of the …

Preeclampsia is a major cause of maternal and perinatal deaths. The aetiology of
preeclampsia is largely unknown but a polygenetic component is assumed. To explore this …

Background Both genetic and environmental factors play a role in the development of autism
spectrum disorder (ASD). This case-control study examined the association between …

S-adenosyl methionine, which is formed from methionine, is an essential methyl donor
within the central nervous system. Methionine is formed by the enzyme methionine synthase …

Background Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases
characterized by lower-limb spastic paraplegia with highly genetic and clinical …

Dietary folates have a key role to play in health, as deficiencies in the intake of these B
vitamins have been implicated in a wide variety of clinical conditions. The reason for this is …

Homocysteine remethylation disorders are rare inherited disorders caused by a deficient
activity of the enzymes involved in the remethylation of homocysteine to methionine. The …

Objective To investigate the relationship between unexplained recurrent pregnancy loss
(URPL) and polymorphisms of homocysteine metabolism-related genes in women. Materials …