Drug repositioning: playing dirty to kill pain

LFS Bastos, MM Coelho - CNS drugs, 2014 - Springer
The number of approved new molecular entity drugs has been decreasing as the
pharmaceutical company investment in research and development is increasing. As we face …

Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress

G Koncsos, ZV Varga, T Baranyai… - American Journal …, 2016 - journals.physiology.org
Although incidence and prevalence of prediabetes are increasing, little is known about its
cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac …

[HTML][HTML] Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic rats

MG Corrêa, SB Sacchetti, FV Ribeiro, SP Pimentel… - PloS one, 2017 - journals.plos.org
This study investigated some immunological features by experimental periodontitis (EP) and
rheumatoid arthritis (RA) disease interact in destructive processes in arthritic rats. Rats were …

Sirolimus-loaded biodegradable implants induce long lasting anti-inflammatory and antiangiogenic effects

BL Costa, R de Resende Machado, MRB Paiva… - Journal of Drug Delivery …, 2018 - Elsevier
Sirolimus is an immunosuppressive drug with activity in rheumatoid arthritis through
inhibition of mTOR and T-lymphocytes activation and proliferation. However, its side effects …

[HTML][HTML] Effect of Xinfeng capsule on nuclear factor Kappa B/tumor necrosis factor alpha and transforming growth factor beta 1/Smads pathways in rats with cardiac …

H Chuanbing, W Lei, L Jian - Journal of Traditional Chinese Medicine, 2016 - Elsevier
Objective To investigate effects of Xinfeng capsule (XFC) on cardiac function in rats with
adjuvant arthritis (AA) and explore the mechanism of these effects. Methods Forty-eight rats …

Recurrent arthritis and immune reconstitution inflammatory syndrome in hematopoietic stem cell transplantation (HSCT)

A López-Iñiguez, KA Carrera-Villanueva… - Bone Marrow …, 2018 - nature.com
Morganella morganni is a facultative anaerobic Gramnegative bacillus. Septic arthritis due to
Morganella sp. is rare, but when it occurs, it usually presents in immunosuppressed …

[PDF][PDF] A STUDY OF THE INFLUENCE OF JUVENILE ADJUVANT ARTHRITIS ON DENTAL HARD TISSUES CONDITION IN EXPERIMENTAL ANIMALS

VM Kulygina, OY Pylypiuk, IV Turchyn… - INDEXED IN …, 2023 - dspace.uzhnu.edu.ua
The aim: To studythe intensity and depth of carious tooth lesions in rats with experimental
juvenile adjuvant-induced arthritis. Materials and methods: An experimental study on a …

[PDF][PDF] Cardiac consequences of metabolic derangements: role of mitochondrial oxidative stress and autophagy

G Koncsos - 2019 - repo.lib.semmelweis.hu
A metabolikus betegségek (pl. az elhízás, a hiperlipidémia vagy a diabétesz) képesek
növelni a kardiovaszkuláris betegségek incidenciáját, ideértve a miokardiális infarktust vagy …

[HTML][HTML] Cardiovascular Mitochondria and Redox Control in Health and Disease: Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress

G Koncsos, ZV Varga, T Baranyai… - American Journal of …, 2016 - ncbi.nlm.nih.gov
Cardiovascular Mitochondria and Redox Control in Health and Disease: Diastolic
dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress - PMC Back to …