Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various
pathogen-and damage-associated molecular pattern molecules playing an important role in …

This study investigated the effects of water-soluble polysaccharide extracted from the
sporoderm-removed spores of Ganoderma lucidum (GLP) against AOM/DSS-induced …

Cellular energy metabolism not only promotes tumor cell growth and metastasis but also
directs immune cell survival, proliferation and the ability to perform specific and functional …

The underlying mechanism of Fusobacterium nucleatum (Fn) in the carcinogenesis of
colorectal cancer (CRC) is poorly understood. Here, we examined Fn abundance in CRC …

Damage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting
immune cells through pattern recognition receptors (PRRs) to begin defense activity …

Ulcerative colitis (UC) has closely been associated with an increased risk of colorectal
cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) …

The tumor microenvironment is host to a complex network of cytokines that contribute to
shaping the intratumoral immune reaction. Chromosomal gains and losses, coupled with …

The immune system encompasses a broad array of defense mechanisms against foreign
threats, including invading pathogens and transformed neoplastic cells. Toll-like receptors …

Purpose Gut microbiota has been reported to contribute to either prevent or promote
colorectal cancer (CRC), and treatment with probiotics might be a promising intervention …