The development of the radioimmunoassay for digoxin by Smith and coworkers in 1969 was
a landmark in digitalis therapy. Since then, the complex pharmacokinetics of digoxin have …

LLOYD H. SMITH, JR, MD:* It is routine to ask each chief medical resident at Moffitt Hospital
to present a medical staffconference near the completion ofhis or her tour ofduty in that …

Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as
cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The …

The process of uptake of cardioactive drugs into the myocardium is a major determinant of
the efficacy and potential toxicity of such agents. Evaluation of responses to anti-arrhythmic …

The aim of this study was to determine if quinidine administration increases steady state
serum digoxin concentration in horses. Digoxin (0.01 mg/kg q. 12 h per os) was …

Digitalis glycosides have a narrow margin between therapeutic and toxic levels. Although
the incidence of digitalis toxicity appears to be decreasing, continuation of digoxin therapy in …

There exist a number of mechanisms to clear xenobiotics from human circulation. For
cationic drugs, clearance is performed by human organic cation transporters 1 and 2 …

Abstract trans-1, 2-Cyclohexanediol, the major metabolite of the cilexetil moiety of
candesartan cilexetil (CC), has been reported to have potent pro-arrhythmic effects in dogs …

Chronic treatment of dogs with digoxin alone, quinidine alone and digoxin in combination
with quinidine was initiated in dogs to assess changes in arrhythmogenic potential …

The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD)
interactions are summarized from a perspective that will allow the readers to apply the …