Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Aneuploidy—the karyotype state in which the number of chromosomes deviates from a
multiple of the haploid chromosome set—is common in cancer, where it is thought to …

Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …

Both the presence of an abnormal complement of chromosomes (aneuploidy) and an
increased frequency of chromosome missegregation (chromosomal instability) are …

Forcing budding yeast to chromatinize their DNA with human histones manifests an abrupt
fitness cost. We previously proposed chromosomal aneuploidy and missense mutations as …

The yeast S. cerevisiae is a unique genetic object for which a wide range of relatively
simple, inexpensive, and non-time-consuming methods have been developed that allow the …

Kinetochores couple chromosomes to the mitotic spindle and transduce the energy of
microtubule depolymerization to segregate the genome during cell division. Kinetochore …

An increased frequency of chromosome segregation errors, known as chromosomal
instability (CIN), leads to accumulation of aneuploid cells with abnormal chromosomal …

Gene loss is common and influences genome evolution trajectories. Multiple adaptive
strategies to compensate for gene loss have been observed, including copy number gain of …