Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Simple Summary Advanced cutaneous melanoma is the most aggressive type of skin cancer
and has variable rates of treatment response. Currently, there are some classes of …

The homogeneous galactoglucan PCP-1C extracted from Poria cocos sclerotium has
multiple biological activities. The present study demonstrated the effect of PCP-1C on the …

The mechanism of tumor drug resistance is complex and may involve stem cell
maintenance, epithelial-mesenchymal transition, the activation of survival signaling …

Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype
(M1 or M2), they can play a role in the initiation or resolution of inflammation. The M1/M2 …

The pathogenesis of Alzheimer's disease (AD) remains unknown till today, hindering the
research and development of AD therapeutics and diagnostics. Circulating extracellular …

Microglia-mediated neuroinflammation is known to play a pivotal role in the pathogenesis of
different neurological diseases. Gastrodin, a phenolic glucoside, has been reported to exert …

The V600E mutation in BRAF is associated with increased phosphorylation of Erk1/2 and
high sensitivity to BRAFi/MEKi combination in metastatic melanoma. In very few patients, a …

Background: Cervical cancer (CC) is characterized by genomic alterations in DNA repair
genes, which could favor treatment with agents causing DNA double-strand breaks (DSBs) …

Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer
with high fatality rates in advanced stages due to its chemoresistant properties. LGSOC is …