Despite nearly five decades of clinical use, vancomycin has retained a significant and
uncontested niche in the antibacterial arsenal because of its consistent activity against …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

Background: Vancomycin is frequently used to treat methicillin-resistant Staphylococcus
aureus infections in pediatric patients. Vancomycin exposure may lead to an increase in …

This review describes the use of vancomycin in neonates over the last three decades. Given
the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase …

Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

This study determines vancomycin (VAN) population pharmacokinetics (PK) in adult patients
with hematological malignancies. VAN serum concentration data (n= 1,004) from therapeutic …

Aims Vancomycin is one of the most evaluated antibiotics in neonates using modeling and
simulation approaches. However no clear consensus on optimal dosing has been achieved …

Until approximately 15 years ago, sponsors rarely included children in the development of
therapeutics. US and European legislation has resulted in an increase in the number of …

Aims Extracorporeal membrane oxygenation (ECMO) is a life support system used during
severe respiratory or cardiorespiratory failure. The objective of this study was to characterize …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …