Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

This study explores the role of the long noncoding RNA (LncRNA) CRNDE in cisplatin
(CDDP) resistance of gastric cancer (GC) cells. Here, we show that LncRNA CRNDE is …

The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Chimeric antigen receptor (CAR) T-cell therapy engineers T-cells to express a synthetic
receptor which redirects effector function to the tumor, to improve efficacy and reduce …

The Myc family of oncogenes is deregulated in many types of cancer, and their over-
expression is often correlated with poor prognosis. The Myc family members are …

Simple Summary Stimulation of the host immune responses, through the use of biotech
drugs that remove a brake on the immune system (immune checkpoint inhibitors), is a …

Introduction Osteosarcoma, the most prevalent primary malignancy of the bone, is often
presented with high-grade subclinical metastatic disease that metastasizes at very early …

Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality
rates worldwide. The occurrence and development of GC is a complex process involving …