Background Very few studies have explored the patterns of cardiovascular health (CVH)
metrics in midlife and late life in relation to risk of dementia. We examined the associations …

Introduction Reliable data on the incidence rates for young‐onset dementia (YOD) are
lacking, but are necessary for research on disease etiology and to raise awareness among …

Although prevention of dementia and late-life cognitive decline is a major public health
priority, there are currently no generally established prevention strategies or operational …

Introduction We conducted a systematic review and meta‐analysis to review the relationship
between midlife dyslipidemia and lifetime incident dementia. Methods The databases …

Several cognitive domains show decline with increasing age, which is associated with
poorer work performance and reduced quality of life. As many nations show a rise in the …

Background Existing evidence suggest an association of cardiovascular health (CVH) level
with cardiometabolic disease (CMD) and mortality, but the effect of CVH on life expectancy …

Background The American Heart Association proposed the Life's Simple 7 (LS7; including
diet, physical activity, smoking, body mass index, blood pressure, plasma fasting glucose …

Although a relationship between traditional cardiovascular risk factors and stroke has long
been recognized, these risk factors likely play a role in other aspects of brain health. Clinical …

This study aimed to investigate the association between the Life's Essential 8 (LE8) score
and incident all-cause dementia (including Alzheimer's disease [AD] and vascular dementia) …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …