Association of type 2 diabetes, according to the number of risk factors within target range, with structural brain abnormalities, cognitive performance, and risk of …

ACE van Gennip, CDA Stehouwer… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Type 2 diabetes is associated with increased risks of cognitive dysfunction and
brain abnormalities. The extent to which risk factor modification can mitigate these risks is …

Resistance and resilience to Alzheimer's disease

CS Latimer, KE Prater… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
Dementia is a significant public health crisis; the most common underlying cause of age-
related cognitive decline and dementia is Alzheimer's disease neuropathologic change …

Associations between life's simple 7 and incident depression among adults aged 50 years and older: A 15-year cohort study

B Gao, S Song, J Guo - Psychiatry research, 2023 - Elsevier
This study aimed to examine association of Life's Simple 7 (LS7), an estimation of
cardiovascular health status, with depression and the modification by genetic risk …

Further understanding of ideal cardiovascular health score metrics and cardiovascular disease

ED Michos, SS Khan - Expert review of cardiovascular therapy, 2021 - Taylor & Francis
ABSTRACT Introduction The American Heart Association (AHA) introduced the construct of
'cardiovascular health (CVH)', to focus on primordial prevention to reduce the burden of …

Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

J Guo, AM Brickman, JJ Manly, C Reitz… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction There is limited and inconsistent reporting on the association between Life's
Simple 7 (LS7) and dementia in the elderly population. Methods Based on the Washington …

Genetic risk, midlife Life's Simple 7, and incident dementia in the atherosclerosis risk in communities study

A Tin, J Bressler, J Simino, KJ Sullivan, H Mei… - Neurology, 2022 - AAN Enterprises
Background and Objectives Higher scores in Life's Simple 7 (LS7), a metric for
cardiovascular and brain health, have been associated with lower risk of dementia. It is …

Subclinical atherosclerosis and brain metabolism in middle-aged individuals: the PESA study

M Cortes-Canteli, JD Gispert, G Salvadó… - Journal of the American …, 2021 - jacc.org
Background Atherosclerosis has been linked to cognitive decline in late life; however, the
impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain …

Sex disparities in cardiovascular health metrics among rural-dwelling older adults in China: a population-based study

X Han, Z Jiang, Y Li, Y Wang, Y Liang, Y Dong, S Tang… - BMC geriatrics, 2021 - Springer
Background Cardiovascular health (CVH) metrics among Chinese older adults are poorly
understood. We investigated sex disparities in CVH metrics and their management among …

Low risk of dementia in patients with newly diagnosed atrial fibrillation and a clustering of healthy lifestyle behaviors: a Nationwide population‐based cohort study

SH Park, SR Lee, EK Choi, HJ Lee… - Journal of the …, 2022 - Am Heart Assoc
Background Limited data are available on the clinical impact of healthy lifestyle behaviors
on the risk of dementia in patients with new‐onset atrial fibrillation (AF). Here, we aimed to …

Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study

YL Zhao, YN Ou, YH Ma, YY Huang, YL Bi… - Alzheimer's Research & …, 2022 - Springer
Introduction This study sought to explore the association between Life's Simple 7 (LS7) and
cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathological biomarkers in the …