Hygiene hypothesis and autoimmune diseases

GAW Rook - Clinical reviews in allergy & immunology, 2012 - Springer
Throughout the twentieth century, there were striking increases in the incidences of many
chronic inflammatory disorders in the rich developed countries. These included autoimmune …

Regulation of immunity and allergy by helminth parasites

RM Maizels - Allergy, 2020 - Wiley Online Library
There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …

The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation

MM Zaiss, A Rapin, L Lebon, LK Dubey, I Mosconi… - Immunity, 2015 - cell.com
Intestinal helminths are potent regulators of their host's immune system and can ameliorate
inflammatory diseases such as allergic asthma. In the present study we have assessed …

[HTML][HTML] Tissue-specific immunity in helminth infections

F Vacca, G Le Gros - Mucosal immunology, 2022 - Elsevier
A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …

Helminth allergens, parasite-specific IgE, and its protective role in human immunity

CM Fitzsimmons, FH Falcone, DW Dunne - Frontiers in immunology, 2014 - frontiersin.org
The Th2 immune response, culminating in eosinophilia and IgE production, is not only
characteristic of allergy but also of infection by parasitic worms (helminths). Anti-parasite IgE …

Chronic helminth infections induce immunomodulation: consequences and mechanisms

E van Riet, FC Hartgers, M Yazdanbakhsh - Immunobiology, 2007 - Elsevier
Worldwide, more than a billion people are infected with helminths. These worm infections
generally do not lead to mortality, however, they are chronic in nature and can lead to …

Unraveling the hygiene hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications

M Versini, PY Jeandel, T Bashi, G Bizzaro, M Blank… - BMC medicine, 2015 - Springer
Abstract Background The Hygiene Hypothesis (HH) attributes the dramatic increase in
autoimmune and allergic diseases observed in recent decades in Western countries to the …

[HTML][HTML] Particularities of allergy in the Tropics

L Caraballo, J Zakzuk, BW Lee, N Acevedo… - World Allergy …, 2016 - Elsevier
Allergic diseases are distributed worldwide and their risk factors and triggers vary according
to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but …

Future therapies for food allergies

A Nowak-Węgrzyn, HA Sampson - Journal of allergy and clinical …, 2011 - Elsevier
Food allergy is an increasingly prevalent problem in westernized countries, and there is an
unmet medical need for an effective form of therapy. A number of therapeutic strategies are …

Interactions between helminth parasites and allergy

PJ Cooper - Current opinion in allergy and clinical immunology, 2009 - journals.lww.com
Interactions between helminth parasites and allergy : Current Opinion in Allergy and Clinical
Immunology Interactions between helminth parasites and allergy : Current Opinion in Allergy …