Resident cardiac macrophages: Heterogeneity and function in health and disease

R Zaman, S Epelman - Immunity, 2022 - cell.com
Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Cardioimmunology: the immune system in cardiac homeostasis and disease

FK Swirski, M Nahrendorf - Nature Reviews Immunology, 2018 - nature.com
The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao… - Nature …, 2020 - nature.com
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases …

Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association

S Van Diepen, JN Katz, NM Albert, TD Henry… - Circulation, 2017 - Am Heart Assoc
Cardiogenic shock is a high-acuity, potentially complex, and hemodynamically diverse state
of end-organ hypoperfusion that is frequently associated with multisystem organ failure …

A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

K Sun, Y Li, J Jin - Signal transduction and targeted therapy, 2021 - nature.com
The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Epidemiology of shock in contemporary cardiac intensive care units: data from the critical care cardiology trials network registry

DD Berg, EA Bohula, S Van Diepen… - … Quality and Outcomes, 2019 - Am Heart Assoc
Background Clinical investigations of shock in cardiac intensive care units (CICUs) have
primarily focused on acute myocardial infarction (AMI) complicated by cardiogenic shock …

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

S Toldo, AG Mauro, Z Cutter… - American Journal of …, 2018 - journals.physiology.org
Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation

M Jung, Y Ma, RP Iyer, KY DeLeon-Pennell… - Basic research in …, 2017 - Springer
Inflammation resolution is important for scar formation following myocardial infarction (MI)
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Coronary microvascular dysfunction: an update

F Crea, PG Camici, CN Bairey Merz - European heart journal, 2014 - academic.oup.com
Many patients undergoing coronary angiography because of chest pain syndromes,
believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries …