The tremendous rate with which data is generated and analysis methods emerge makes it
increasingly difficult to keep track of their domain of applicability, assumptions, limitations …

Alternative processing of nascent mRNAs is widespread in eukaryotic organisms and greatly
impacts the output of gene expression. Specifically, alternative cleavage and …

Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …

The sessile nature of plants confines their responsiveness to changing environmental
conditions. Gene expression regulation becomes a paramount mechanism for plants to …

Bone contributes to the maintenance of vital biological activities. At the cellular level,
multiple types of skeletal cells, including skeletal stem and progenitor cells (SSPCs) …

Introduction Single-cell RNA-seq (scRNA-seq) technologies have been widely used to
reveal the diversity and complexity of cells, and pioneering studies on scRNA-seq in plants …

Motivation Alternative polyadenylation (APA) is a widespread post-transcriptional regulatory
mechanism across all eukaryotes. With the accumulation of genome-wide APA sites …

Manipulation using alternative exon splicing (AES), alternative transcription start (ATS), and
alternative polyadenylation (APA) sites are key to transcript diversity underlying health and …

全球人口持续增长, 极端天气频发等因素给全球粮食安全带来新的挑战, 需要开辟新的育种途径
提升作物育种性状. 近年来, 生物技术(biotechnology, BT) 与人工智能, 大数据等信息技术 …

The integration of high-throughput genomic sequencing and advanced AI algorithms is
revolutionizing the fields of medicine and pharmaceuticals, particularly in the areas of …