Unprecedented therapeutic targeting of previously undruggable proteins has now been
achieved by molecular‐glue‐mediated proximity‐induced degradation. As a small GTPase …

In eukaryotic cells, the ubiquitin–proteasome system (UPS) plays a crucial role in selectively
breaking down specific proteins. The ability of the UPS to target proteins effectively and …

Proteolysis-targeting chimera (PROTAC) is a powerful technology that can effectively trigger
the degradation of target proteins. The intricate interplay among various factors leads to a …

Molecular glues are small molecules, typically smaller than PROTACs, and usually with
improved physicochemical properties that aim to stabilise the interaction between two …

Background Mixed-lineage leukemia (MLL) fusion gene caused by chromosomal
rearrangement is a dominant oncogenic driver in leukemia. Due to having diverse MLL …

Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular
responses to metabolic and other stresses. During nutrient replete and stressor-free …

Drug discovery efforts have traditionally focused on developing small molecules to directly
inhibit or modulate the enzymatic activity of disease-relevant proteins. However, the …

Targeted protein degradation is an important mechanism carried out by the cellular
machinery, one that is gaining momentum as an exploitable strategy for the development of …

Targeted protein degradation (TPD) has emerged as a powerful strategy to selectively
eliminate cellular proteins using small-molecule degraders, offering therapeutic promise for …

Programmed death ligand 1 (PD-L1) is a protein overexpressed in numerous tumor cells as
an essential immune checkpoint that can facilitate immune escape of tumor cells through …