Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

The brain, long thought to be isolated from the peripheral immune system, is increasingly
recognized to be integrated into a systemic immunological network. These conduits of …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
caused by CNS-infiltrating leukocytes, including TH17 cells that are critical mediators of …

Multiple Sclerosis (MS) is, to date, an incurable disease of the nervous system characterized
by demyelination. Several genetic mutations are associated with the disease but they are …

Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful
infections and malignant transformation but also can instigate autoimmune reactions. Similar …

Emerging evidence shows that the meninges conduct essential immune surveillance and
immune defense at the brain border, and the dysfunction of meningeal immunity contributes …

Background and Objectives Tertiary lymphoid structures and aggregates are reported in the
meninges of patients with multiple sclerosis (MS), especially at the progressive stage, and …

Immune surveillance and adaptive immune responses, involving continuously circulating
and tissue-resident T-lymphocytes, provide host defense against infectious agents and …

Altered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in
blood, cerebrospinal fluid, and brain tissue of people with relapsing-remitting multiple …

Therapeutic options against multiple sclerosis (MS) preventing T cell migration to the central
nervous system (CNS) have remarkable clinical effects against the relapsing-remitting …