Small RNAs in bacteria and archaea: who they are, what they do, and how they do it

EGH Wagner, P Romby - Advances in genetics, 2015 - Elsevier
Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

RNA-based recognition and targeting: sowing the seeds of specificity

SA Gorski, J Vogel, JA Doudna - Nature Reviews Molecular Cell …, 2017 - nature.com
RNA is involved in the regulation of multiple cellular processes, often by forming sequence-
specific base pairs with cellular RNA or DNA targets that must be identified among the large …

Global mapping of small RNA-target interactions in bacteria

S Melamed, A Peer, R Faigenbaum-Romm, YE Gatt… - Molecular cell, 2016 - cell.com
Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …

Hfq chaperone brings speed dating to bacterial sRNA

A Santiago‐Frangos… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …

Impact of bacterial sRNAs in stress responses

E Holmqvist, EGH Wagner - Biochemical Society Transactions, 2017 - portlandpress.com
Bacterial life is harsh and involves numerous environmental and internal challenges that are
perceived as stresses. Consequently, adequate responses to survive, cope with, and …

CRISPR RNA-dependent binding and cleavage of endogenous RNAs by the Campylobacter jejuni Cas9

G Dugar, RT Leenay, SK Eisenbart, T Bischler, BU Aul… - Molecular cell, 2018 - cell.com
Cas9 nucleases naturally utilize CRISPR RNAs (crRNAs) to silence foreign double-stranded
DNA. While recent work has shown that some Cas9 nucleases can also target RNA, RNA …

Prevalence of small base-pairing RNAs derived from diverse genomic loci

PP Adams, G Storz - Biochimica Et Biophysica Acta (BBA)-Gene …, 2020 - Elsevier
Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in
fine-tuning the levels and translation of their target transcripts across a variety of model and …

C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA

A Santiago-Frangos, K Kavita… - Proceedings of the …, 2016 - National Acad Sciences
The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs
(sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and …

Accelerating discovery and functional analysis of small RNAs with new technologies

L Barquist, J Vogel - Annual review of genetics, 2015 - annualreviews.org
Over the past decade, bacterial small RNAs (sRNAs) have gone from a biological curiosity to
being recognized as a major class of regulatory molecules. High-throughput methods for …

Coxiella burnetii and Related Tick Endosymbionts Evolved from Pathogenic Ancestors

AE Brenner, S Muñoz-Leal, M Sachan… - Genome biology and …, 2021 - academic.oup.com
Both symbiotic and pathogenic bacteria in the family Coxiellaceae cause morbidity and
mortality in humans and animals. For instance, Coxiella-like endosymbionts (CLEs) improve …