Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

Y Gerakis, C Hetz - The FEBS journal, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …

The neurobiological basis of sleep: Insights from Drosophila

S Ly, AI Pack, N Naidoo - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
Sleep is a biological enigma that has raised numerous questions about the inner workings
of the brain. The fundamental question of why our nervous systems have evolved to require …

Relationships among dietary nutrients and subjective sleep, objective sleep, and napping in women

MA Grandner, DF Kripke, N Naidoo, RD Langer - Sleep medicine, 2010 - Elsevier
OBJECTIVE: To describe which dietary nutrient variables are related to subjective and
objective habitual sleep and subjective and objective napping. METHODS: Participants …

Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

JM Hafycz, E Strus, N Naidoo - Aging Cell, 2022 - Wiley Online Library
As the aging population grows, the need to understand age‐related changes in health is
vital. Two prominent behavioral changes that occur with age are disrupted sleep and …

Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders

N Naidoo - Sleep medicine reviews, 2009 - Elsevier
Recent transcript profiling and microarray studies are beginning to unveil some of the
mysteries of sleep. One of the most important clues has been the identification of the …

Many faces of sleep regulation: beyond the time of day and prior wake time

JM Duhart, S Inami, K Koh - The FEBS journal, 2023 - Wiley Online Library
The two‐process model of sleep regulation posits two main processes regulating sleep: the
circadian process controlled by the circadian clock and the homeostatic process that …

[HTML][HTML] Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the potential roles of protein synthesis and other cellular processes

D Picchioni, RM Reith, JL Nadel, CB Smith - Brain sciences, 2014 - mdpi.com
Sleep is important for neural plasticity, and plasticity underlies sleep-dependent memory
consolidation. It is widely appreciated that protein synthesis plays an essential role in neural …

Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis

MK Brown, MT Chan, JE Zimmerman, AI Pack… - Neurobiology of …, 2014 - Elsevier
Alterations in the quality, quantity, and architecture of baseline and recovery sleep have
been shown to occur during aging. Sleep deprivation induces endoplasmic reticular (ER) …

[PDF][PDF] Hypothalamic eIF2α signaling regulates food intake

AC Maurin, A Benani, A Lorsignol, X Brenachot, L Parry… - Cell reports, 2014 - cell.com
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a
highly conserved signal implicated in the cellular adaptation to numerous stresses such as …

What are microarrays teaching us about sleep?

M Mackiewicz, JE Zimmerman, KR Shockley… - Trends in molecular …, 2009 - cell.com
Many fundamental questions about sleep remain unanswered. The presence of sleep
across phyla suggests that it must serve a basic cellular and/or molecular function …