Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

Neural circuits are assembled with remarkable precision during embryonic development,
and the selectivity inherent in their formation helps to define the behavioural repertoire of the …

Indian hedgehog (Ihh), one of the three mammalian hedgehog (Hh) proteins, coordinates
proliferation and differentiation of chondrocytes during endochondral bone development …

Genetic analyses in Drosophila have demonstrated that the multipass membrane protein
Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic …

Abstract Background: The Hedgehog (Hh) family of secreted proteins is involved in a
number of developmental processes as well as in cancer. Genetic and biochemical data …

The secreted proteins of the Hedgehog family have been implicated in many different
processes in vertebrate development including cartilage differentiation, myotome and …

The secretion of Sonic hedgehog (Shh) from the notochord and floor plate appears to
generate a ventral-to-dorsal gradient of Shh activity that directs progenitor cell identity and …

Abstract Background: Sonic hedgehog (Shh) is well known for its role in patterning tissues,
including structures of the head. Haploinsufficiency for SHH in humans results in …

Hair follicles form in prenatal skin and mature in the postnatal period, establishing a growth
cycle in 3 phases: telogen (resting), anagen (growth), and catagen (regression). Based on …