[HTML][HTML] The foundation and architecture of precision medicine in neurology and psychiatry
Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
The normative modeling framework for computational psychiatry
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …
differences at the level of a single subject or observation in relation to a reference model. It …
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
Psychiatric diagnosis and treatment in the 21st century: paradigm shifts versus incremental integration
Psychiatry has always been characterized by a range of different models of and approaches
to mental disorder, which have sometimes brought progress in clinical practice, but have …
to mental disorder, which have sometimes brought progress in clinical practice, but have …
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry
Every year, millions of brain magnetic resonance imaging (MRI) scans are acquired in
hospitals across the world. These have the potential to revolutionize our understanding of …
hospitals across the world. These have the potential to revolutionize our understanding of …
Psychopathy
Psychopathy is a personality disorder characterized by a constellation of affective,
interpersonal, lifestyle and antisocial features whose antecedents can be identified in a …
interpersonal, lifestyle and antisocial features whose antecedents can be identified in a …
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …
arise from molecular perturbations or connectome miswiring. The unique and shared …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …