Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Diabetic nephropathy (DN) is the most common microvascular complication in diabetes and
one of the leading causes of end-stage renal disease. The standard treatments for patients …

Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to
heart failure (HF) development has been undermined in current clinical practice. This is …

Background In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains,
which then form stable crosslinks. We hypothesized that MRI with the allysine-targeted …

Background Diabetic kidney disease (DKD) is a severe complication of diabetes. Currently,
no effective measures are available to reduce the risk of DKD progression. This study aimed …

Diabetic nephropathy (DN) remains the most common reason for end-stage renal disease
and a leading cause of kidney replacement therapy. Multifactorial pathophysiological …

Sestrin2 regulates cell homeostasis and is an upstream signaling molecule for several
signaling pathways. Sestrin2 leads to AMP‐activated protein kinase‐(AMPK‐) and GTPase …

Chronic kidney disease (CKD) is characterized by renal parenchymal damage leading to a
reduction in the glomerular filtration rate. The inflammatory response plays a pivotal role in …

Background Diabetic nephropathy (DN) is a prevalent complication of diabetes, in which
inflammation and fibrosis are the significant pathogenesis. Periostin is a matricellular protein …

Background: To evaluate the efficacy and safety of Keluoxin (KLX) capsules and provide
validated evidence for the application of KLX in the treatment of diabetic kidney disease …