The high recurrence rate and the low overall survival in ovarian cancer suggest that a more
specific therapeutic approach in addition to conventional treatment is required. Translational …

Around 70% of ovarian cancer patients relapse after primary cytoreductive surgery and
standard first-line chemotherapy. The biology of relapse remains unclear, but cancer stem …

The formation and progression of tumors in humans are linked to the abnormal development
of new blood vessels known as neo-angiogenesis. Angiogenesis is a broad word that …

Breast cancer is the most common malignancy in women worldwide, and ovarian cancer is
the most lethal gynecological malignancy. Women carrying a BRCA1/2 mutation have a very …

With a wide range of available cytotoxic therapeutics, the main focus of current cancer
research is to deliver them specifically to the cancer cells, minimizing toxicity against healthy …

Recent breakthroughs in our understanding of the molecular pathophysiology of retinal
vascular disease have allowed us to specifically target pathological angiogenesis while …

Abstract Purpose of Review The purpose of this review is to discuss the current
understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis …

Aims Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers.
Currently, the first-line OC treatment consists of cytoreductive surgery and platinum-based …

Abstract The PI3K/AKT/mTOR signaling pathway is considered as a promising therapeutic
target in the treatment of ovarian cancer (OC); however, inhibition of this pathway only …

Novel concepts and understanding of receptors lead to discoveries and optimization of
many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases …