Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion
channels present in the central and peripheral nervous systems, that are permeable to mono …

Tobacco smoking causes high rates of mortality and morbidity throughout the world. Despite
the availability of smoking-cessation medications, maintenance of long-term abstinence is …

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus.
The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate …

Tobacco smoking continues to be a major global health hazard despite significant public
awareness of its harmful consequences. Although several treatment options are currently …

Although a relative newcomer to the nicotinic acetylcholine receptor (nAChR) family,
substantial evidence suggests that α6 containing nAChRs play a key role in CNS function …

Intravenous nicotine self-administration is the most direct measure of nicotine reinforcement
in laboratory animals, but this procedure has proven difficult to establish in mice. We found …

Introduction: Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine
receptors (nAChR) maybe involved in the etiology of withdrawal symptoms. Methods: We …