[HTML][HTML] An ecotoxicological view on neurotoxicity assessment
The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …
Neurotoxicology of nanomaterials
WK Boyes, C van Thriel - Chemical research in toxicology, 2020 - ACS Publications
The remarkable advances coming about through nanotechnology promise to revolutionize
many aspects of modern life; however, these advances come with a responsibility for due …
many aspects of modern life; however, these advances come with a responsibility for due …
[HTML][HTML] A framework for chemical safety assessment incorporating new approach methodologies within REACH
N Ball, R Bars, PA Botham, A Cuciureanu… - Archives of …, 2022 - Springer
The long-term investment in new approach methodologies (NAMs) within the EU and other
parts of the world is beginning to result in an emerging consensus of how to use information …
parts of the world is beginning to result in an emerging consensus of how to use information …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Establishment of an a priori protocol for the implementation and interpretation of an in‐vitro testing battery for the assessment of developmental neurotoxicity
S Masjosthusmann, J Blum, K Bartmann… - EFSA Supporting …, 2020 - Wiley Online Library
In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …
methods with high readiness and data generated therefrom. The methods underwent afit‐for …
[HTML][HTML] Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
A Bal-Price, F Pistollato, M Sachana, SK Bopp… - Toxicology and applied …, 2018 - Elsevier
Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
[HTML][HTML] Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals
J Blum, S Masjosthusmann, K Bartmann, F Bendt… - Chemosphere, 2023 - Elsevier
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …
exposome. However, DNT data from animal studies are available for only a small …
[HTML][HTML] Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
D Loser, K Grillberger, MG Hinojosa, J Blum… - Archives of …, 2021 - Springer
Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …
[HTML][HTML] Development and analysis of an adverse outcome pathway network for human neurotoxicity
N Spinu, A Bal-Price, MTD Cronin, SJ Enoch… - Archives of …, 2019 - Springer
An adverse outcome pathway (AOP) network is an attempt to represent the complexity of
systems toxicology. This study illustrates how an AOP network can be derived and analysed …
systems toxicology. This study illustrates how an AOP network can be derived and analysed …
[HTML][HTML] Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes
E Fritsche, P Grandjean, KM Crofton, M Aschner… - Toxicology and applied …, 2018 - Elsevier
This consensus statement voices the agreement of scientific stakeholders from regulatory
agencies, academia and industry that a new framework needs adopting for assessment of …
agencies, academia and industry that a new framework needs adopting for assessment of …