Diabetes mellitus and cardiovascular disease: Emerging therapeutic approaches

AM Schmidt - Arteriosclerosis, thrombosis, and vascular biology, 2019 - Am Heart Assoc
Cardiovascular disease remains a leading cause of morbidity and mortality in people with
types 1 or 2 diabetes mellitus. Although beneficial roles for strict control of hyperglycemia …

Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis

MS Hussain, O Afzal, G Gupta, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

S Xu, D Kamato, PJ Little, S Nakagawa… - Pharmacology & …, 2019 - Elsevier
Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Noncoding RNAs in vascular diseases

N Jaé, S Dimmeler - Circulation research, 2020 - Am Heart Assoc
The advent of deep sequencing technologies led to the identification of a considerable
amount of noncoding RNA transcripts, which are increasingly recognized for their functions …

MALAT1 long non-coding RNA and breast cancer

G Arun, DL Spector - RNA biology, 2019 - Taylor & Francis
Non-coding RNAs are becoming major players in disease pathogenesis such as cancer.
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched …

[HTML][HTML] Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms

R Jayasuriya, K Ganesan, B Xu… - Biomedicine & …, 2022 - Elsevier
Long non-coding RNAs (lncRNAs) are the novel class of transcripts involved in
transcriptional, post-transcriptional, translational, and post-translational regulation of …

LncRNA-MALAT1 promotes neovascularization in diabetic retinopathy through regulating miR-125b/VE-cadherin axis

P Liu, SB Jia, JM Shi, WJ Li, LS Tang, XH Zhu… - Bioscience …, 2019 - portlandpress.com
Background: Diabetic retinopathy (DR) is currently the leading cause of blindness and visual
disability in adults with diabetes mellitus (DM). Neovascularization has been identified as an …

Epi-drugs in heart failure

E Gorica, SA Mohammed, S Ambrosini… - Frontiers in …, 2022 - frontiersin.org
Unveiling the secrets of genome's flexibility does not only foster new research in the field,
but also gives rise to the exploration and development of novel epigenetic-based therapies …

Multifaceted functions of protein kinase D in pathological processes and human diseases

X Zhang, J Connelly, Y Chao, QJ Wang - Biomolecules, 2021 - mdpi.com
Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the
signaling network of the second messenger diacylglycerol. The three family members …

Role of Nrf2 in MALAT1/HIF-1α loop on the regulation of angiogenesis in diabetic foot ulcer

R Jayasuriya, U Dhamodharan, AN Karan… - Free Radical Biology …, 2020 - Elsevier
Diabetic non healing wounds often result in significant morbidity and mortality. The number
of effective targets to detect these wounds are meagre. Slow lymphangiogenesis is one of …