A differentiation block and an accumulation of immature myeloid cells characterize acute
myelogenous leukemia (AML). However, native AML cells usually show some …

A differentiation block with accumulation of immature myeloid cells characterizes acute
myelogenous leukemia (AML). However, native AML cells often show some morphological …

Mutations of signal-induced proliferation-associated gene 1 (SIPA1), a RAP1 GTPase-
activating protein, were reported in patients with juvenile myelomonocytic leukemia, a …

Several types of peripheral blood cells express ABC transporters. ABCC4 (MRP4) and
ABCC5 (MRP5) localize to different cellular sites and fulfill lineage‐specific functions such …

Leukemia cell lines were treated with eltrombopag or thrombopoietin and their proliferative
response was determined. Eltrombopag did not increase proliferation of cell lines that did …

Targeted suicide gene therapy for Epstein-Barr virus (EBV)-associated neoplasms was
attempted by using EBV-based plasmid vectors coupled with hemagglutinating virus of …

The factor which is the primary regulator of megakaryocyte and platelet production has
recently been identified as the ligand for the receptor Mpl. This discovery has resulted in …

The present study was aimed at devising an efficient nonviral strategy for suicide gene
therapy of hepatocellular carcinoma (HCC). To improve the efficiency of DNA delivery and …

Thrombopoietin (TPO), the major growth factor for cells of the megakaryocytic lineage, is
removed from circulation by binding to c-mpl receptors present on platelets and …

PTPases are key signaling molecules and targets for developing novel therapeutics. We
have studied the in vitro biological activity of PTPase inhibitor sodium stibogluconate (SS) …