While great progress has been made in the understanding of neurological illnesses, the
pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also …

The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

This Perspective will examine the organization of intrastriatal circuitry, review recent findings
in this area, and discuss how the pattern of connectivity between striatal neurons might give …

Our original review,“Heterogeneity and Diversity of Striatal GABAergic Interneurons,” to
which this is an invited update, was published in December, 2010 in Frontiers is …

Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles
in behavior by coordinating the networks of medium spiny cells that relay motor output …

Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells
implicated in two seemingly independent network functions: gain control and network …

Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …

Effective evaluation of costs and benefits is a core survival capacity that in humans is
considered as optimal," rational" decision-making. This capacity is vulnerable in …

Behavior is readily classified into patterns of movements with inferred common goals—
actions. Goals may be discrete; movements are continuous. Through the careful study of …