The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms
involved in the formation and maintenance of the vascular network in embryonal and post …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial
organization of endothelial cells. This mechanism is regulated by a balance between …

Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have …

Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause
pathophysiological processes of persistent and neuropathic pain. Thereby, the activation …

Due to the aging population in the world, neurodegenerative diseases have become a
serious public health issue that greatly impacts patients' quality of life and adds a huge …

The common and severe psychiatric disorders, including major depressive disorder (MDD)
and bipolar disorder (BD), are associated with inflammation, oxidative stress and changes in …

Cytochrome P450 (CYP) enzymes are frequently referred to as the third pathway for the
metabolism of arachidonic acid. While it is true that these enzymes generate arachidonic …