[HTML][HTML] A theory of hippocampal function: new developments

ET Rolls, A Treves - Progress in Neurobiology, 2024 - Elsevier
We develop further here the only quantitative theory of the storage of information in the
hippocampal episodic memory system and its recall back to the neocortex. The theory is …

Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory

G Berdugo‐Vega, S Dhingra, F Calegari - The EMBO Journal, 2023 - embopress.org
For decades, the mammalian hippocampus has been the focus of cellular, anatomical,
behavioral, and computational studies aimed at understanding the fundamental …

[HTML][HTML] Natural killer cells in the central nervous system

Z Ning, Y Liu, D Guo, WJ Lin, Y Tang - Cell Communication and Signaling, 2023 - Springer
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work
as both cytotoxic effectors and immune regulators. Accumulating evidence points to …

[HTML][HTML] An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

ED Nelson, M Tippani, AD Ramnauth, HR Divecha… - BioRxiv, 2024 - ncbi.nlm.nih.gov
The hippocampus contains many unique cell types, which serve the structure's specialized
functions, including learning, memory and cognition. These cells have distinct spatial …

[HTML][HTML] Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure

K Wardhani, S Yazzie, O Edeh, M Grimes, C Dixson… - Scientific Reports, 2024 - nature.com
Woodsmoke (WS) exposure is associated with significant health-related sequelae. Different
populations can potentially exhibit varying susceptibility, based on endocrine phenotypes, to …

[HTML][HTML] Expression of GCaMP6s in the dentate gyrus induces tonic–clonic seizures

S Teng, W Wang, JJJ Wen, J Wang, GF Turi, Y Peng - Scientific Reports, 2024 - nature.com
GCaMP is a genetically encoded calcium indicator (GECI) widely used in neuroscience
research. It measures intracellular Ca2+ level by fluorescence changes as it directly binds to …

[HTML][HTML] Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome

JD Martinez, LG Wilson, WP Brancaleone, KG Peterson… - Cell Reports, 2024 - cell.com
Fragile X syndrome (FXS) is associated with disrupted cognition and sleep abnormalities.
Sleep loss negatively impacts cognitive function, and one untested possibility is that …

[HTML][HTML] Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus

AD Bird, H Cuntz, P Jedlicka - PLOS Computational Biology, 2024 - journals.plos.org
Pattern separation is a valuable computational function performed by neuronal circuits, such
as the dentate gyrus, where dissimilarity between inputs is increased, reducing noise and …

Imbalance between hippocampal projection cell and parvalbumin interneuron architecture increases epileptic susceptibility in mouse model of methyl CpG binding …

J Ge, S Xie, J Duan, B Tian, P Ren, E Hu, Q Huang… - …, 2024 - Wiley Online Library
Abstract Objective Methyl CpG‐binding protein 2 (MECP2) duplication syndrome is a rare X‐
linked genomic disorder affecting predominantly males, which is usually manifested as …

[HTML][HTML] Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities

V Granato, L Congiu, I Jakovcevski, R Kleene… - Biomolecules, 2024 - mdpi.com
The X-chromosome-linked cell adhesion molecule L1 (L1CAM), a glycoprotein mainly
expressed by neurons in the central and peripheral nervous systems, has been implicated in …