Neurodegenerative diseases (amyloid diseases such as Alzheimer's and Parkinson's),
stemming from protein misfolding and aggregation, encompass a spectrum of disorders with …

The interplay between protein folding and biological activity is crucial, with the integrity of the
proteome being paramount to ensuring effective biological function execution. In this study …

Lipid nanoparticles (LNPs) have become pivotal in advancing modern medicine, from
mRNA-based vaccines to gene editing with CRISPR-Cas9 systems. Though LNPs based …

Background Protein misfolding and aggregation can lead to various diseases. Recent
studies have shed light on the aggregated protein in breast cancer pathology, which …

As a consequence of somatosensory nervous system injury or disease, neuropathic pain is
commonly associated with chemotherapies, known as chemotherapy-induced peripheral …

Extensive production of recombinant protein is essential for use in various fields. Bacterial
cells, especially the Escherichia coli (E. coli) expression system, are widely used for the …

Aggregation of microtubule-associated protein tau (MAPT/tau) into conformationally distinct
fibrils underpins neurodegenerative tauopathies. Fluorescent probes (fluoroprobes), such as …

Chiral nanomaterials with distinctive physical and chemical properties, including circular
dichroism, circularly polarized photoluminescence, nonlinear optics, and spintronics, have …

The relationship between cancer and neurodegeneration has spurred extensive scientific
discourse, challenging their historical classification as distinct disorders. While cancer …

As an atom-economic way of carbon-nitrogen bond formation, hydroaminations are great
tool for make amines, hydrazines, and other nitrogen-containing heterocycles. Specifically …