[HTML][HTML] Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

S Lin, Q Yin, Q Zhong, FL Lv, Y Zhou, JQ Li… - Journal of …, 2012 - Springer
Background Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-
induced neurological deficits; however, the signaling pathways are not apparent by which …

Edema from intracerebral hemorrhage: the role of thrombin

KR Lee, GP Colon, AL Betz, RF Keep, S Kim… - Journal of …, 1996 - thejns.org
✓ The mechanism by which intracerebral hemorrhage leads to the formation of brain edema
is unknown. This study assesses the components of blood to determine if any are toxic to …

Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage

AR Zazulia, MN Diringer, TO Videen… - Journal of Cerebral …, 2001 - journals.sagepub.com
A zone of hypoperfusion surrounding acute intracerebral hemorrhage (ICH) has been
interpreted as regional ischemia. To determine if ischemia is present in the periclot area, the …

Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage

EC Song, K Chu, SW Jeong, KH Jung, SH Kim, M Kim… - Stroke, 2003 - Am Heart Assoc
Background and Purpose—Hyperglycemia has a deleterious effect on brain ischemia.
However, the effect of hyperglycemia in intracerebral hemorrhage (ICH) is not well known …

Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter

KR Wagner, G Xi, Y Hua, M Kleinholz… - Stroke, 1996 - Am Heart Assoc
Background and Purpose The mechanisms underlying brain injury from intracerebral
hemorrhage (ICH) are complex and poorly understood. To comprehensively examine …

Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study

SA Mayer, A Lignelli, ME Fink, DB Kessler, CE Thomas… - Stroke, 1998 - Am Heart Assoc
Background and Purpose—Secondary brain injury and edema formation contribute
significantly to morbidity and mortality after intracerebral hemorrhage (ICH). The …

急性脑出血继发缺血半暗带的研究进展

刘庆新, 张苏明 - 国外医学: 脑血管疾病分册, 2002 - cqvip.com
急性脑出血后血肿周边和远隔部位可出现不同程度的局部脑血流下降, 其下降程度可能与血肿的
大小, 部位及出血时间有关. 动物实验已证明, 血肿周边可出现缺血半暗带, 但在临床试验中并未 …

Molecular signatures of brain injury after intracerebral hemorrhage

J Castillo, A Davalos, J Álvarez–Sabín, JM Pumar… - Neurology, 2002 - AAN Enterprises
Background: The mechanisms of cellular death in the tissue surrounding an intracerebral
hemorrhage (ICH) are not defined. Objective: To investigate the relationship of markers of …

[HTML][HTML] Spontaneous intracerebral hemorrhage: a review

ME Fewel, BG Thompson, JT Hoff - Neurosurgical focus, 2003 - thejns.org
Spontaneous intracerebral hemorrhage (SICH) is a blood clot that arises in the brain
parenchyma in the absence of trauma or surgery. This entity accounts for 10 to 15% of all …

Brain injury after intracerebral hemorrhage: the role of thrombin and iron

Y Hua, RF Keep, JT Hoff, G Xi - Stroke, 2007 - Am Heart Assoc
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The
mechanisms underlying ICH-induced brain injury have become better understood during the …