Brain edema after intracerebral hemorrhage: mechanisms, treatment options, management strategies, and operative indications
R Thiex, SE Tsirka - Neurosurgical focus, 2007 - thejns.org
✓ Primary intracerebral hemorrhage (ICH) is associated with a high mortality rate and
severe morbidity. The treatment of choice is still controversial, given that data from several …
severe morbidity. The treatment of choice is still controversial, given that data from several …
Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage
CS Kidwell, JL Saver, J Mattiello, S Warach… - Neurology, 2001 - AAN Enterprises
Background: It has been suggested that a zone of perihematomal ischemia analogous to an
ischemic penumbra exists in patients with primary intracerebral hemorrhage (ICH). Diffusion …
ischemic penumbra exists in patients with primary intracerebral hemorrhage (ICH). Diffusion …
Tumor necrosis factor-α increases in the brain after intracerebral hemorrhage and thrombin stimulation
Y Hua, J Wu, RF Keep, T Nakamura, JT Hoff, G Xi - Neurosurgery, 2006 - journals.lww.com
OBJECTIVE: The goals of this study were 1) to determine the effects of intracerebral
hemorrhage (ICH) on brain tumor necrosis factor (TNF)-α levels, which are still controversial; …
hemorrhage (ICH) on brain tumor necrosis factor (TNF)-α levels, which are still controversial; …
Role of glibenclamide in brain injury after intracerebral hemorrhage
B Jiang, L Li, Q Chen, Y Tao, L Yang, B Zhang… - Translational stroke …, 2017 - Springer
Brain edema following intracerebral hemorrhage (ICH) causes severe secondary brain
injury, and no efficient pharmacological preventions are available. The present study was …
injury, and no efficient pharmacological preventions are available. The present study was …
Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage
E Tejima, BQ Zhao, K Tsuji, A Rosell… - Journal of Cerebral …, 2007 - journals.sagepub.com
We tested the hypothesis that astrocytic matrix metalloproteinase-9 (MMP-9) mediates
hemorrhagic brain edema. In a clinical case of hemorrhagic stroke, MMP-9 co-localized with …
hemorrhagic brain edema. In a clinical case of hemorrhagic stroke, MMP-9 co-localized with …
Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is one of the most common causes of fatal stroke, yet has no
specific drug therapies. Many attempts at passive intravenous (IV) delivery in ICH have …
specific drug therapies. Many attempts at passive intravenous (IV) delivery in ICH have …
A mouse model of intracerebral hemorrhage using autologous blood infusion
MA Rynkowski, GH Kim, RJ Komotar, ML Otten… - Nature protocols, 2008 - nature.com
The development of controllable and reproducible animal models of intracerebral
hemorrhage (ICH) is essential for the systematic study of the pathophysiology and treatment …
hemorrhage (ICH) is essential for the systematic study of the pathophysiology and treatment …
HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats
M Ohnishi, H Katsuki, C Fukutomi, M Takahashi… - …, 2011 - Elsevier
Thrombin activates immunocompetent microglia and increases release of inflammatory
cytokines under intracerebral hemorrhage (ICH) insults. Also, thrombin injection into the …
cytokines under intracerebral hemorrhage (ICH) insults. Also, thrombin injection into the …
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice
J Tang, J Liu, C Zhou, JS Alexander… - Journal of Cerebral …, 2004 - journals.sagepub.com
Matrix metalloproteinase-9 (MMP-9) participates in the disregulation of blood–brain barrier
during hemorrhagic transformation, and exacerbates brain injury after cerebral ischemia …
during hemorrhagic transformation, and exacerbates brain injury after cerebral ischemia …