Object. The authors previously demonstrated, in a large-animal intracerebral hemorrhage
(ICH) model, that markedly edematous (“translucent”) white matter regions (> 10% increases …

The c‐Jun N‐terminal kinase (JNK) is induced by cerebral ischemia and injurious blood
components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition …

Spreading depression (SD) is a slowly propagating neuronal depolarization that underlies
certain neurologic conditions. The wave-like pattern of its propagation suggests that SD …

Object. Development of edema is known to contribute to poor outcome after spontaneous
intracerebral hemorrhage (ICH). Recent research has identified thrombin as a key mediator …

Iron compounds formed in the degradation of a hematoma can accelerate the formation of
free radicals in adjacent ischemic or hypoperfused tissue. The purpose of this study was to …

Intracerebral hemorrhages (ICH) represent about 10–15% of all strokes per year in the
United States alone. Key variables influencing the long-term outcome after ICH are …

Haemorrhagic stroke represents a significant public health burden, yet our knowledge and
ability to treat this type of stroke are lacking. Previously we showed that we can target …

✓ The coagulation cascade plays an important role in brain edema formation caused by
intracerebral blood. In particular, thrombin produces brain injury via direct brain cell toxicity …

Gene knockout or transgenic animals may assist in elucidating the mechanisms of brain
injury after intracerebral hemorrhage (ICH). However, almost all commercially available …