Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage
KR Wagner, G Xi, Y Hua, M Kleinholz… - Journal of …, 1998 - thejns.org
Object. The authors previously demonstrated, in a large-animal intracerebral hemorrhage
(ICH) model, that markedly edematous (“translucent”) white matter regions (> 10% increases …
(ICH) model, that markedly edematous (“translucent”) white matter regions (> 10% increases …
Role of c‐Jun N‐terminal kinase in early brain injury after subarachnoid hemorrhage
H Yatsushige, RP Ostrowski… - Journal of …, 2007 - Wiley Online Library
The c‐Jun N‐terminal kinase (JNK) is induced by cerebral ischemia and injurious blood
components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition …
components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition …
Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression
N Zhou, RL Rungta, A Malik, H Han… - Journal of Cerebral …, 2013 - journals.sagepub.com
Spreading depression (SD) is a slowly propagating neuronal depolarization that underlies
certain neurologic conditions. The wave-like pattern of its propagation suggests that SD …
certain neurologic conditions. The wave-like pattern of its propagation suggests that SD …
Edema after intracerebral hemorrhage: correlations with coagulation parameters and treatment
LH Sansing, EA Kaznatcheeva, CJ Perkins… - Journal of …, 2003 - thejns.org
Object. Development of edema is known to contribute to poor outcome after spontaneous
intracerebral hemorrhage (ICH). Recent research has identified thrombin as a key mediator …
intracerebral hemorrhage (ICH). Recent research has identified thrombin as a key mediator …
Protective effects of free radical inhibitors in intracerebral hemorrhage in rat
J Peeling, HJ Yan, SG Chen, M Campbell… - Brain research, 1998 - Elsevier
Iron compounds formed in the degradation of a hematoma can accelerate the formation of
free radicals in adjacent ischemic or hypoperfused tissue. The purpose of this study was to …
free radicals in adjacent ischemic or hypoperfused tissue. The purpose of this study was to …
Secondary hematoma expansion and perihemorrhagic edema after intracerebral hemorrhage: from bench work to practical aspects
K Lim-Hing, F Rincon - Frontiers in Neurology, 2017 - frontiersin.org
Intracerebral hemorrhages (ICH) represent about 10–15% of all strokes per year in the
United States alone. Key variables influencing the long-term outcome after ICH are …
United States alone. Key variables influencing the long-term outcome after ICH are …
[HTML][HTML] Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption
Haemorrhagic stroke represents a significant public health burden, yet our knowledge and
ability to treat this type of stroke are lacking. Previously we showed that we can target …
ability to treat this type of stroke are lacking. Previously we showed that we can target …
Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage
KR Lee, I Drury, E Vitarbo, JT Hoff - Journal of neurosurgery, 1997 - thejns.org
✓ The coagulation cascade plays an important role in brain edema formation caused by
intracerebral blood. In particular, thrombin produces brain injury via direct brain cell toxicity …
intracerebral blood. In particular, thrombin produces brain injury via direct brain cell toxicity …
Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice
T Nakamura, G Xi, Y Hua, T Schallert… - Journal of Cerebral …, 2004 - journals.sagepub.com
Gene knockout or transgenic animals may assist in elucidating the mechanisms of brain
injury after intracerebral hemorrhage (ICH). However, almost all commercially available …
injury after intracerebral hemorrhage (ICH). However, almost all commercially available …