Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there
is a growing body of evidence showing that, in the hippocampus, this process contributes to …

Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …

The cellular composition of brains shows largely conserved, gradual evolutionary trends
between species. In the primate spinal cord, however, the glia–neuron ratio was reported to …

A number of age-associated neurodegenerative diseases, including Alzheimer's disease
(AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), possess a shared …

Background Despite numerous studies on the enteric nervous system (ENS), we lack
fundamental knowledge on neuronal densities or total neuron numbers in different species …

Background Aging is an inevitable physiological process, associated with a decline in
cognitive function. Recently, metformin, as the first-line treatment for type II diabetes, has …

The renin–angiotensin system (RAS) is dysregulated in Alzheimer's disease (AD). In this
study, we have explored the hypothesis that an age-related imbalance in brain RAS is a …

Aging-affected cellular compositions of the spinal cord are diverse and region specific. Age
leads to the accumulation of abnormal protein aggregates and dysregulation of proteostasis …

Brain aging is associated with cognitive decline, memory loss and many neurodegenerative
disorders. The mammalian brain has distinct structural regions that perform specific …