Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable
alternative to carbapenems for treating infections due to ESBL-producing Enterobacterales …

Aminoglycosides are important treatment options for serious lung infections, but modeling
analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We …

Introduction Population pharmacokinetic studies of β-lactam antimicrobials in critically ill
patients derive models that inform their dosing. In non-linear mixed-effects modelling …

The development of broad-spectrum antibiotics to control multidrug-resistant bacteria is an
outdated business model. This strategy has led to the introduction of highly effective …

Temocillin is active against Gram-negative bacteria, including many extended-spectrum β-
lactamase (ESBL)-producing Enterobacterales. We studied its pharmacokinetics in plasma …

Background Temocillin is a β-lactam that is not hydrolysed by ESBLs Objectives To describe
the real-life use of temocillin, to assess its effectiveness in infections caused by ESBL …

Background Expanding the use of temocillin could be an important weapon in the fight
against antimicrobial resistance. However, EUCAST defined clinical breakpoints for a limited …

Background With increasing resistance to common antibiotics the treatment of urinary tract
infections has become challenging and alternative therapeutic options are needed. In the …

Background Cerebral ventriculitis might be caused by Gram-negative bacteria, including
ESBL producers. Temocillin may be a useful treatment option in this scenario; however, no …

Temocillin is used for the treatment of various infections caused by Enterobacterales. The
pharmacokinetic (PK)/pharmacodynamic (PD) index that is best correlated with the activity of …