Chronic obstructive pulmonary disease (COPD) is one of the most common chronic
respiratory diseases with high morbidity and mortality. It has become the fifth most burdened …

Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …

Aims Pyroptosis and inflammation are involved in the development of chronic obstructive
pulmonary disease (COPD). However, the cigarette smoke-mediated mechanism of COPD …

Intervertebral disc degeneration (IDD) is a common cause of joint-related chronic disability
in elderly individuals worldwide. It seriously impacts the quality of life and inflicts a …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Various genetic and environmental risk factors have been implicated in the pathogenesis of
amyotrophic lateral sclerosis (ALS). Despite this, the cause of most ALS cases remains …

Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory skin disorder with a
prevalence of around 1% and a profound impact on patients' quality of life. Characteristic …

To characterize transcriptomic changes in endothelial cells (ECs) infected by coronaviruses,
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …

Our current understanding of the pathogenesis of skin aging includes the role of ultraviolet
light, visible light, infrared, pollution, cigarette smoke and other environmental exposures …