[HTML][HTML] A comprehensive overview of globally approved JAK inhibitors
Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …
[HTML][HTML] Small molecule EGFR inhibitors as anti-cancer agents: discovery, mechanisms of action, and opportunities
T Zubair, D Bandyopadhyay - International Journal of Molecular Sciences, 2023 - mdpi.com
Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are
also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a …
also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a …
[HTML][HTML] Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
[HTML][HTML] Targeting EGFR in melanoma–the sea of possibilities to overcome drug resistance
J Pastwińska, K Karaś, I Karwaciak… - Biochimica et Biophysica …, 2022 - Elsevier
Melanoma is considered one of the most aggressive skin cancers. It spreads and
metastasizes quickly and is intrinsically resistant to most conventional chemotherapeutics …
metastasizes quickly and is intrinsically resistant to most conventional chemotherapeutics …
[HTML][HTML] Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma
Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …
signaling cascades are stimulated via genetic modifications in upstream signaling …
[HTML][HTML] The importance of the pyrazole scaffold in the design of protein kinases inhibitors as targeted anticancer therapies
The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma
Non-small cell lung carcinoma (NSCLC) is the most common cancer globally.
Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers …
Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers …
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico …
Abstract Treatment options for the management of breast cancer are still inadequate. This
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
[HTML][HTML] DNA damage response mechanisms in head and neck cancer: significant implications for therapy and survival
C Papalouka, M Adamaki, P Batsaki… - International Journal of …, 2023 - mdpi.com
Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …
[HTML][HTML] Pareto optimization to accelerate multi-objective virtual screening
The discovery of therapeutic molecules is fundamentally a multi-objective optimization
problem. One formulation of the problem is to identify molecules that simultaneously exhibit …
problem. One formulation of the problem is to identify molecules that simultaneously exhibit …