Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

H1 and H2 histamine receptor antagonists, although developed many decades ago, are still
effective for the treatment of allergic and gastric acid–related conditions. This article focuses …

Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central
nervous system. We have reported that histamine induces microglia activation and releases …

Background: The treatment of non-small-cell lung cancer (NSCLC) involves platinum-based
chemotherapy. It is typically accompanied by chemoresistance resulting from antioxidant …

The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …

Alzheimer's disease (AD) is one of the leading causes for disability and death affecting
millions of people worldwide. Thus, novel therapeutic strategies are needed to reduce brain …

Histamine [H] is a well-known biogenic amine whose biological properties were first
characterized more than 100 years ago [1, 2]. It plays a significant role in the human …

Itch and pain are closely related but distinct sensations that share largely overlapping
mediators and receptors. We hypothesized that the novel, multi-target compound E153 has …

Histamine is a naturally occurring biogenic monoamine that acts at both central and
peripheral levels, serving a crucial role in regulating a range of physiological processes in …