The relationship between variations in the apoAI-CIII-AIV gene cluster and plasma lipid traits
has been recognized for at least 15 years. Most studies have been focused upon the …

Genetic variability at the APOA1/C3/A4/A5 cluster has been examined in relation to lipid
metabolism and cardiovascular disease risk. However, the findings are inconsistent. This is …

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte
function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …

HNF-4α is a transcription factor of the nuclear hormone receptor family that is expressed in
the hepatic diverticulum at the onset of liver development. Mouse embryos lacking HNF-4α …

The cell cycle inhibitor p21/WAF1/Cip1 is expressed in many cell types and is regulated by
p53-dependent and p53-independent mechanisms. p21 is an important regulator of …

The expression of the apolipoprotein AI gene (apoA-I) in hepatocytes is repressed by pro-
inflammatory cytokines such as IL-1β and TNFα. In this work, we have demonstrated that …

Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched transcription factor that is crucial in
the regulation of a large number of genes involved in glucose, cholesterol, and fatty acid …

It is well known that type-2 diabetes mellitus (T2D) is increasing worldwide, but also the
autoimmune form, type-1 diabetes (T1D), is affecting more people. The latest estimation from …

The present review summarizes recent advances in the transcriptional regulation of the
human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and …

Epidemiological studies have shown that low plasma levels of High Density Lipoprotein
Cholesterol (HDL-C) are associated with an increased risk for myocardial infarction. These …