Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Mechanical regulation of bone remodeling

L Wang, X You, L Zhang, C Zhang, W Zou - Bone research, 2022 - nature.com
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

The principles of directed cell migration

S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

ERK signalling: a master regulator of cell behaviour, life and fate

H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

Review of the endocannabinoid system

HC Lu, K Mackie - Biological Psychiatry: Cognitive Neuroscience and …, 2021 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

V Venturini, F Pezzano, F Catala Castro, HM Häkkinen… - Science, 2020 - science.org
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity

Y Kinashi, K Hase - Frontiers in immunology, 2021 - frontiersin.org
The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

Rho GTPase signaling in cancer progression and dissemination

E Crosas-Molist, R Samain… - Physiological …, 2022 - journals.physiology.org
Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Chemically fueled self‐assembly in biology and chemistry

K Das, L Gabrielli, LJ Prins - Angewandte Chemie International …, 2021 - Wiley Online Library
Life is a non‐equilibrium state of matter maintained at the expense of energy. Nature uses
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

SA Scott, J Fu, PV Chang - Proceedings of the National …, 2020 - National Acad Sciences
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small …