Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

We review the morphofunctional characteristics of pericytes and report our observations.
After a brief historical background, we consider the following aspects of pericytes: A) Origin …

In spite of the advances in the knowledge of adult stem cells (ASCs) during the past few
years, their natural activities in vivo are still poorly understood. Mesenchymal stem cells …

The acute phase response is an orchestrated response to tissue injury, infection or
inflammation. A prominent feature of this response is the induction of acute phase proteins …

Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited
therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell …

T he retractile and remodeling phenomena accompanying and, in pathologic situations,
following the healing of an open wound have attracted the interest of physicians and …

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

BACKGROUND.: The alpha isotype of actin expressed by hepatic stellate cells reflects their
activation to myofibroblast-like cell and has been directly related to experimental liver …

Hepatic fibrosis is a wound-healing process that occurs when the liver is injured chronically.
Hepatic stellate cells (HSC) are responsible for the excess production of extracellular matrix …

The hepatic stellate (Ito) cell lies within the space of Disse and has a variety of functions.
Stellate cells store vitamin A in characteristic lipid droplets. In the normal human liver, the …