Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …
previous genome-wide studies were unable to identify risk loci among individuals of …
[HTML][HTML] Genetics factors in major depression disease
M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …
According to the World Health Organization, about 350 million people in the world are …
An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
We report a multi-omic resource generated by applying quantitative trait locus (xQTL)
analyses to RNA sequence, DNA methylation and histone acetylation data from the …
analyses to RNA sequence, DNA methylation and histone acetylation data from the …
[HTML][HTML] Largest GWAS of PTSD (N= 20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Abstract The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
A unified model of depression: Integrating clinical, cognitive, biological, and evolutionary perspectives
AT Beck, K Bredemeier - Clinical Psychological Science, 2016 - journals.sagepub.com
We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …
perceived loss of an investment in a vital resource such as a relationship, group identity, or …
What are'good'depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis
Abstract Background The symptoms for Major Depression (MD) defined in the DSM-5 differ
markedly from symptoms assessed in common rating scales, and the empirical question …
markedly from symptoms assessed in common rating scales, and the empirical question …
[HTML][HTML] The genetics of stress-related disorders: PTSD, depression, and anxiety disorders
JW Smoller - Neuropsychopharmacology, 2016 - nature.com
Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …
factors: genetic vulnerability and environmental stressors. An important role for …
Genetics and genomics of psychiatric disease
DH Geschwind, J Flint - Science, 2015 - science.org
Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …
The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?
CB Nemeroff - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …
associated with high levels of morbidity and mortality. Patients with major depression are …
[HTML][HTML] Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …