Neuroticism is a personality trait of fundamental importance for psychological well-being and
public health. It is strongly associated with major depressive disorder (MDD) and several …

Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-
genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, and …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even
psychotic symptoms and signs that can cause substantial impairments in quality of life and …

Brain gene expression profiling studies of suicide and depression using oligonucleotide
microarrays have often failed to distinguish these two phenotypes. Moreover, next …

Background Although depression is the leading cause of disability worldwide, its
pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) …

Few would argue that depression research in the last two decades has led to major
improvements of clinical care for patients. The tools and insights we have at our disposal …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

BackgroundMajor depressive disorder (MDD) is a common and disabling condition with well-
established heritability and environmental risk factors. Gene–environment interaction …

Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a
known heritable component, a large meta-analysis of genome-wide association studies …