Epigenetic mechanisms of major depression: targeting neuronal plasticity
S Uchida, H Yamagata, T Seki… - Psychiatry and clinical …, 2018 - Wiley Online Library
Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …
than 350 million people globally. Major depressive disorder is etiologically complex and …
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …
The epigenome in neurodevelopmental disorders
J Reichard, G Zimmer-Bensch - Frontiers in Neuroscience, 2021 - frontiersin.org
Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …
schizophrenia, are characterized by diverse facets of neurological and psychiatric …
Rapid genotype imputation from sequence without reference panels
Inexpensive genotyping methods are essential for genetic studies requiring large sample
sizes. In human studies, array-based microarrays and high-density haplotype reference …
sizes. In human studies, array-based microarrays and high-density haplotype reference …
Genetics of depression: progress at last
Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …
association studies that identify genetic variants associated with depression and outline the …
The genetics of depression: successful genome-wide association studies introduce new challenges
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …
yielded more than 80 replicated loci and brought back the excitement that had evaporated …
Mood, the circadian system, and melanopsin retinal ganglion cells
L Lazzerini Ospri, G Prusky… - Annual review of …, 2017 - annualreviews.org
The discovery of a third type of photoreceptors in the mammalian retina, intrinsically
photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on …
photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on …
Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect
M Ikeda, A Takahashi, Y Kamatani… - Schizophrenia …, 2019 - academic.oup.com
Genome-wide association studies (GWASs) have identified> 100 susceptibility loci for
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by …
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by …
Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
S Liu, J Xiu, C Zhu, K Meng, C Li, R Han, T Du… - Nature …, 2021 - nature.com
Post-transcriptional modifications of RNA, such as RNA methylation, can epigenetically
regulate behavior, for instance learning and memory. However, it is unclear whether RNA …
regulate behavior, for instance learning and memory. However, it is unclear whether RNA …
Genetic heterogeneity and subtypes of major depression
Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …